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Interplay of T-cell receptor and interleukin-2 signalling in Vγ2Vδ2 T-cell cytotoxicity

Human peripheral blood Vγ2Vδ2 T cells are important for host defence and tumour immunity. Their unusual T-cell receptor (TCR) recognizes small molecule phosphoantigens; stimulated cells produce inflammatory cytokines and are potently cytotoxic for a variety of tumours. However, molecular mechanisms...

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Hlavní autoři: Li, Haishan, David Pauza, C
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015079/
https://ncbi.nlm.nih.gov/pubmed/20738419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2010.03343.x
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