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Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes

The CD28 gene is similarly down-regulated in CD4(+) lymphocytes from both healthy elderly people and patients with rheumatoid arthritis (RA) because of impaired protein-binding activity of the ‘α’ sequence in its promoter region. Other genes important for the CD4(+) cell function may share that sequ...

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Detalhes bibliográficos
Main Authors: Soroczyńska-Cybula, Monika, Bryl, Ewa, Smoleńska, Żaneta, Witkowski, Jacek M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015077/
https://ncbi.nlm.nih.gov/pubmed/20738421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2010.03341.x
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