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Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes
The CD28 gene is similarly down-regulated in CD4(+) lymphocytes from both healthy elderly people and patients with rheumatoid arthritis (RA) because of impaired protein-binding activity of the ‘α’ sequence in its promoter region. Other genes important for the CD4(+) cell function may share that sequ...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Science Inc
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3015077/ https://ncbi.nlm.nih.gov/pubmed/20738421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2010.03341.x |
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