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Quantitative Comparison of Intracellular Unpacking Kinetics of Polyplexes by a Model Constructed From Quantum Dot-FRET

A major challenge for non-viral gene delivery is gaining a mechanistic understanding of the rate-limiting steps. A critical barrier in polyplex-mediated gene delivery is the timely unpacking of polyplexes within the target cell to liberate DNA for efficient gene transfer. In this study, the componen...

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Detalhes bibliográficos
Main Authors: Chen, Hunter H, Ho, Yi-Ping, Jiang, Xuan, Mao, Hai-Quan, Wang, Tza-Huei, Leong, Kam W
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014860/
https://ncbi.nlm.nih.gov/pubmed/18180773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300392
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