Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APP(SL) and APP(SL)/PS1(M146L) Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?

There is evidence linking sphingolipid abnormalities, APP processing, and neuronal death in Alzheimer's disease (AD). We previously reported a strong elevation of ceramide levels in the brain of the APP(SL)/PS1Ki mouse model of AD, preceding the neuronal death. To extend these findings, we anal...

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Hlavní autoři: Barrier, Laurence, Fauconneau, Bernard, Noël, Anastasia, Ingrand, Sabrina
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE-Hindawi Access to Research 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014734/
https://ncbi.nlm.nih.gov/pubmed/21234372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/920958
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