Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E-cadherin). This binding is mediated by the large cytoplasmic loop of PS1 and requires the membrane-proximal cytoplasmic sequence 604–615 of mature E-cadherin. This sequence...

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Bibliografiske detaljer
Main Authors: Baki, Lia, Marambaud, Philippe, Efthimiopoulos, Spiros, Georgakopoulos, Anastasios, Wen, Paul, Cui, Wen, Shioi, Junichi, Koo, Eduard, Ozawa, Masayuki, Friedrich, Victor L., Robakis, Nikolaos K.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC30147/
https://ncbi.nlm.nih.gov/pubmed/11226248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041603398
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