Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E-cadherin). This binding is mediated by the large cytoplasmic loop of PS1 and requires the membrane-proximal cytoplasmic sequence 604–615 of mature E-cadherin. This sequence is al...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Baki, Lia, Marambaud, Philippe, Efthimiopoulos, Spiros, Georgakopoulos, Anastasios, Wen, Paul, Cui, Wen, Shioi, Junichi, Koo, Eduard, Ozawa, Masayuki, Friedrich, Victor L., Robakis, Nikolaos K.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30147/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226248/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.041603398
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