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Total Synthesis of Plukenetione A

We describe an alkylative dearomatization/acid-mediated adamantane annulation sequence which allows facile access to type A polyprenylated acylphloroglucinol (PPAP) natural products including plukenetione A. Introduction of the 2-methyl-1-propenyl moiety was achieved via stereodivergent S(N)2 and S(...

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Autors principals: Zhang, Qiang, Mitasev, Branko, Qi, Ji, Porco, John A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014579/
https://ncbi.nlm.nih.gov/pubmed/20843036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105784s
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