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Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin
Three heterozygous missense mutations in the motor domain of myosin 1c (Myo1c), which mediates adaptation in the inner ear, are associated with bilateral sensorineural hearing loss in humans. With transient kinetic analyses, steady-state ATPase and motility assays, and homology modeling, we studied...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014424/ https://ncbi.nlm.nih.gov/pubmed/20640478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0448-x |
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