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Acetylcholine Receptor (AChR) α5 Subunit Variant Associated with Risk for Nicotine Dependence and Lung Cancer Reduces (α4β2)(2)α5 AChR Function
Genomic studies have identified a D398N variation in the α5 subunit of nicotinic acetylcholine receptors (AChRs) that increases risk of nicotine dependence and lung cancer. (α4β2)(2)α5 AChRs are a significant brain presynaptic subtype in brain. Their high sensitivity to activation by nicotine and hi...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014277/ https://ncbi.nlm.nih.gov/pubmed/20881005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.066357 |
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