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RNA Aptamers Directed to Human Immunodeficiency Virus Type 1 Gag Polyprotein Bind to the Matrix and Nucleocapsid Domains and Inhibit Virus Production

Gag orchestrates the assembly and release of human immunodeficiency virus type 1 (HIV-1) particles. We explored here the potential of anti-Gag RNA aptamers to inhibit HIV-1 replication. In vitro, RNA aptamers raised against an HIV-1 Gag protein, lacking the N-terminal myristate and the C-terminal p6...

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Autori principali: Ramalingam, Dhivya, Duclair, Sonald, Datta, Siddhartha A. K., Ellington, Andrew, Rein, Alan, Prasad, Vinayaka R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014162/
https://ncbi.nlm.nih.gov/pubmed/20980522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02626-09
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