Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate

The nsp1 protein of transmissible gastroenteritis virus (TGEV), an alphacoronavirus, efficiently suppressed protein synthesis in mammalian cells. Unlike the nsp1 protein of severe acute respiratory syndrome coronavirus, a betacoronavirus, the TGEV nsp1 protein was unable to bind 40S ribosomal subuni...

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Detalhes bibliográficos
Main Authors: Huang, Cheng, Lokugamage, Kumari G., Rozovics, Janet M., Narayanan, Krishna, Semler, Bert L., Makino, Shinji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014157/
https://ncbi.nlm.nih.gov/pubmed/21047955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01806-10
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