N-{N-[2-(3,5-Difluoro­phenyl)acetyl]-(S)-alanyl}-(S)-phenyl­glycine tert-butyl ester (DAPT): an inhibitor of γ-secretase, revealing fine electronic and hydrogen-bonding features

The title compound, C(23)H(26)F(2)N(2)O(4), is a dipeptidic inhibitor of γ-secretase, one of the enzymes involved in Alzheimer’s dis­ease. The mol­ecule adopts a compact conformation, without intra­molecular hydrogen bonds. In the crystal structure, one of the amide N atoms forms the only inter­mole...

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Autores principales: Czerwinski, Andrzej, Valenzuela, Francisco, Afonine, Pavel, Dauter, Miroslawa, Dauter, Zbigniew
Formato: Artigo
Lenguaje:Inglês
Publicado: International Union of Crystallography 2010
Materias:
Organic Compounds
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014104/
https://ncbi.nlm.nih.gov/pubmed/21123889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0108270110044136
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