Glomerular Structure and Function Require Paracrine, Not Autocrine, VEGF–VEGFR-2 Signaling

VEGF is a potent vascular growth factor produced by podocytes in the developing and mature glomerulus. Specific deletion of VEGF from podocytes causes glomerular abnormalities including profound endothelial cell injury, suggesting that paracrine signaling is critical for maintaining the glomerular f...

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Autori principali: Sison, Karen, Eremina, Vera, Baelde, Hans, Min, Wang, Hirashima, Masanori, Fantus, I. George, Quaggin, Susan E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2010
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013545/
https://ncbi.nlm.nih.gov/pubmed/20688931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010030295
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