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Trps1 Haploinsufficiency Promotes Renal Fibrosis by Increasing Arkadia Expression
Mutations in TRPS1 cause tricho-rhino-pharyngeal syndrome (TRPS). Trps1 is essential for nephron development, acting downstream of Bmp7. Because Bmp7 counteracts epithelial-to-mesenchymal transition (EMT) and reverses chronic renal injury, we examined the function of Trps1 in renal fibrosis. Immunoh...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3013522/ https://ncbi.nlm.nih.gov/pubmed/20507941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009121201 |
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