Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI [Image: see text]

OBJECTIVES: In Alzheimer disease (AD), mounting evidence points to a greater role for synaptic loss than neuronal loss. Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates...

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Detalhes bibliográficos
Main Authors: Kerchner, G.A., Hess, C.P., Hammond-Rosenbluth, K.E., Xu, D., Rabinovici, G.D., Kelley, D.A.C., Vigneron, D.B., Nelson, S.J., Miller, B.L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Academy of Neurology 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013485/
https://ncbi.nlm.nih.gov/pubmed/20938031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181f736a1
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