Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

Haematopoietic stem cells in umbilical cord blood are an attractive target for gene therapy of inborn errors of metabolism. Three neonates with severe combined immunodeficiency were treated by retroviral-mediated transduction of the CD34+ cells from their umbilical cord blood with a normal human ade...

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Main Authors: Kohn, Donald B., Weinberg, Kenneth I., Nolta, Jan A., Heiss, Linda N., Lenarsky, Carl, Crooks, Gay M., Hanley, Mary E., Annett, Geralyn, Brooks, Judith S., El-Khoureiy, Anthony, Lawrence, Kim, Wells, Susie, Moen, Robert C., Bastian, John, Williams-Herman, Debora E., Elder, Melissa, Wara, Diane, Bowen, Thomas, Hershfield, Michael S., Mullen, Craig A., Blaese, R. Michael, Parkman, Robertson
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013367/
https://ncbi.nlm.nih.gov/pubmed/7489356
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