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Thrombin Induces Macrophage Migration Inhibitory Factor Release and Upregulation in Urothelium: A Possible Contribution to Bladder Inflammation

PURPOSE: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine expressed by urothelial cells that mediates bladder inflammation. We investigated the effect of stimulation with thrombin, a Protease Activated Receptor-1 (PAR1) agonist, on MIF release and MIF mRNA upregulation in...

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Autors principals: Vera, Pedro L., Wolfe, Terra E., Braley, Alexander E., Meyer-Siegler, Katherine L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013117/
https://ncbi.nlm.nih.gov/pubmed/21209875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015904
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