Histidine 103 in Fra2 Is an Iron-Sulfur Cluster Ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required for in Vivo Iron Signaling in Yeast

The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae. Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response...

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Autores principales: Li, Haoran, Mapolelo, Daphne T., Dingra, Nin N., Keller, Greg, Riggs-Gelasco, Pamela J., Winge, Dennis R., Johnson, Michael K., Outten, Caryn E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013046/
https://ncbi.nlm.nih.gov/pubmed/20978135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.184176
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