Mechanisms of Autoinhibition of IRF-7 and a Probable Model for Inactivation of IRF-7 by Kaposi's Sarcoma-associated Herpesvirus Protein ORF45

IRF-7 is the master regulator of type I interferon-dependent immune responses controlling both innate and adaptive immunity. Given the significance of IRF-7 in the induction of immune responses, many viruses have developed strategies to inhibit its activity to evade or antagonize host antiviral resp...

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Autores principales: Sathish, Narayanan, Zhu, Fan Xiu, Golub, Ellis E., Liang, Qiming, Yuan, Yan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013033/
https://ncbi.nlm.nih.gov/pubmed/20980251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150920
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