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Engineered External Guide Sequences Effectively Block Viral Gene Expression and Replication in Cultured Cells
Ribonuclease P (RNase P) complexed with external guide sequence (EGS) represents a novel nucleic acid-based gene interference approach to modulate gene expression. We have previously used an in vitro selection procedure to generate EGS variants that efficiently direct human RNase P to cleave a targe...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012989/ https://ncbi.nlm.nih.gov/pubmed/20980254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.158857 |
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