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X-ray and Biochemical Analysis of N370S Mutant Human Acid β-Glucosidase
Gaucher disease is caused by mutations in the enzyme acid β-glucosidase (GCase), the most common of which is the substitution of serine for asparagine at residue 370 (N370S). To characterize the nature of this mutation, we expressed human N370S GCase in insect cells and compared the x-ray structure...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012987/ https://ncbi.nlm.nih.gov/pubmed/20980263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150433 |
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