X-ray and Biochemical Analysis of N370S Mutant Human Acid β-Glucosidase

Gaucher disease is caused by mutations in the enzyme acid β-glucosidase (GCase), the most common of which is the substitution of serine for asparagine at residue 370 (N370S). To characterize the nature of this mutation, we expressed human N370S GCase in insect cells and compared the x-ray structure...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Wei, Ronnie R., Hughes, Heather, Boucher, Susan, Bird, Julie J., Guziewicz, Nicholas, Van Patten, Scott M., Qiu, Huawei, Pan, Clark Qun, Edmunds, Tim
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012987/
https://ncbi.nlm.nih.gov/pubmed/20980263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150433
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars