Gene Expression Profiling Reveals New Aspects of PIK3CA Mutation in ERalpha-Positive Breast Cancer: Major Implication of the Wnt Signaling Pathway

BACKGROUND: The PI3K/AKT pathway plays a pivotal role in breast cancer development and maintenance. PIK3CA, encoding the PI3K catalytic subunit, is the oncogene exhibiting a high frequency of gain-of-function mutations leading to PI3K/AKT pathway activation in breast cancer. PIK3CA mutations have be...

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Detalhes bibliográficos
Main Authors: Cizkova, Magdalena, Cizeron-Clairac, Géraldine, Vacher, Sophie, Susini, Aurélie, Andrieu, Catherine, Lidereau, Rosette, Bièche, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012715/
https://ncbi.nlm.nih.gov/pubmed/21209903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015647
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