NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation

The integrin αIIbβ3 is a transmembrane (TM) heterodimeric adhesion receptor that exists in equilibrium between resting and active ligand binding conformations. In resting αIIbβ3, the TM and cytoplasmic domains of αIIb and β3 form a heterodimer that constrains αIIbβ3 in its resting conformation. To s...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Metcalf, Douglas G., Moore, David T., Wu, Yibing, Kielec, Joseph M., Molnar, Kathleen, Valentine, Kathleen G., Wand, A. Joshua, Bennett, Joel S., DeGrado, William F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012518/
https://ncbi.nlm.nih.gov/pubmed/21156831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015545107
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker