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NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation
The integrin αIIbβ3 is a transmembrane (TM) heterodimeric adhesion receptor that exists in equilibrium between resting and active ligand binding conformations. In resting αIIbβ3, the TM and cytoplasmic domains of αIIb and β3 form a heterodimer that constrains αIIbβ3 in its resting conformation. To s...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012518/ https://ncbi.nlm.nih.gov/pubmed/21156831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015545107 |
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