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The ubiquitin E3 ligase RAUL negatively regulates type I interferon through ubiquitination of the transcription factors IRF7 and IRF3
In the course of combating infectious agents, type I Interferon (IFN) needs a timely down-regulation mechanism to avoid detrimental overreaction. Here we showed a mechanism for restraining type I IFN responses, which relied on a HECT domain ubiquitin (Ub) E3 ligase, RAUL. RAUL limited type I IFN pro...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012379/ https://ncbi.nlm.nih.gov/pubmed/21167755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.11.027 |
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