FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction

OBJECTIVE: A strong association between genetic variants and obesity was found for the fat mass and obesity-associated gene (FTO). However, few details are known concerning the expression and function of FTO in skeletal muscle of patients with metabolic diseases. RESEARCH DESIGN AND METHODS: We inve...

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Main Authors: Bravard, Amélie, Lefai, Etienne, Meugnier, Emmanuelle, Pesenti, Sandra, Disse, Emmanuel, Vouillarmet, Julien, Peretti, Nöel, Rabasa-Lhoret, Rémi, Laville, Martine, Vidal, Hubert, Rieusset, Jennifer
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Pathophysiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012179/
https://ncbi.nlm.nih.gov/pubmed/20943749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0281
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