Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase

OBJECTIVE: We investigated the function of the Prep1 gene in insulin-dependent glucose homeostasis in liver. RESEARCH DESIGN AND METHODS: Prep1 action on insulin glucoregulatory function has been analyzed in liver of Prep1-hypomorphic mice (Prep1(i/i)), which express 2–3% of Prep1 mRNA. RESULTS: Bas...

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Autors principals: Oriente, Francesco, Iovino, Salvatore, Cabaro, Serena, Cassese, Angela, Longobardi, Elena, Miele, Claudia, Ungaro, Paola, Formisano, Pietro, Blasi, Francesco, Beguinot, Francesco
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012165/
https://ncbi.nlm.nih.gov/pubmed/20864515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0860
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