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Distinct roles for the N- and C-terminal regions in the cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from cabbage butterfly, against mammalian cells

Pierisin-1 is an 850-aa cytotoxic protein found in the cabbage butterfly, Pieris rapae, and has been suggested to consist of an N-terminal region with ADP-ribosyltransferase domain and of a C-terminal region that might have a receptor-binding domain. To elucidate the role of each region, we investig...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kanazawa, Takashi, Watanabe, Masahiko, Matsushima-Hibiya, Yuko, Kono, Takuo, Tanaka, Noriaki, Koyama, Kotaro, Sugimura, Takashi, Wakabayashi, Keiji
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30120/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226221/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051628898
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