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Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions.

Chinese hamster ovary (CHO) cells transfected with the integrin alpha 2 subunit formed a stable VLA-2 heterodimer that mediated cell adhesion to collagen. Within CHO cells spread on collagen, but not fibronectin, wild-type alpha 2 subunit localized into focal adhesion complexes (FACs). In contrast,...

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Main Authors: Kawaguchi, S, Bergelson, J M, Finberg, R W, Hemler, M E
格式: Artigo
語言:Inglês
出版: 1994
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC301121/
https://ncbi.nlm.nih.gov/pubmed/7841525
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