ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification

Gene fusions prevalent in prostate cancer (CaP) lead to the elevated expression of the ERG proto-oncogene. ERG activation present in 50–70% of prostate tumors underscores one of the most common oncogenic alterations in CaP. Despite numerous reports of gene fusions and mRNA expression, ERG oncoprotei...

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Главные авторы: Furusato, B, Tan, S-H, Young, D, Dobi, A, Sun, C, Mohamed, A A, Thangapazham, R, Chen, Y, McMaster, G, Sreenath, T, Petrovics, G, McLeod, D G, Srivastava, S, Sesterhenn, I A
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2010
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010744/
https://ncbi.nlm.nih.gov/pubmed/20585344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pcan.2010.23
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