Outcome-related metabolomic patterns from (1)H/(31)P NMR after mild hypothermia treatments of oxygen–glucose deprivation in a neonatal brain slice model of asphyxia

Human clinical trials using 72 hours of mild hypothermia (32°C–34°C) after neonatal asphyxia have found substantially improved neurologic outcomes. As temperature changes differently modulate numerous metabolite fluxes and concentrations, we hypothesized that (1)H/(31)P nuclear magnetic resonance (N...

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Detalhes bibliográficos
Main Authors: Liu, Jia, Litt, Lawrence, Segal, Mark R, Kelly, Mark J S, Yoshihara, Hikari A I, James, Thomas L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010526/
https://ncbi.nlm.nih.gov/pubmed/20717124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.125
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