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INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis
Cytosolic inhibitor of Nrf2 (INrf2) is an adaptor protein that mediates ubiquitination/degradation of NF-E2-related factor 2 (Nrf2), a master regulator of cytoprotective gene expression. In this paper, we demonstrate that INrf2 degrades endogenous antiapoptotic B-cell CLL/lymphoma 2 (Bcl-2) protein...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010499/ https://ncbi.nlm.nih.gov/pubmed/20865015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.114 |
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