Structure-based design of NS2 mutants for attenuated influenza A virus vaccines

We previously characterized the matrix 1 (M1)-binding domain of the influenza A virus NS2/nuclear export protein (NEP), reporting a critical role for the tryptophan (W78) residue that is surrounded by a cluster of glutamate residues in the C-terminal region that interacts with the M1 protein (Akarsu...

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Main Authors: Akarsu, Hatice, Iwatsuki-Horimoto, Kiyoko, Noda, Takeshi, Kawakami, Eiryo, Katsura, Hiroaki, Baudin, Florence, Horimoto, Taisuke, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010430/
https://ncbi.nlm.nih.gov/pubmed/20970464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2010.10.014
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