Ligase Detection Reaction for the Analysis of Point Mutations using Free Solution Conjugate Electrophoresis in a Polymer Microfluidic Device

We have developed a new method for the analysis of low abundant point mutations in genomic DNA using a combination of an allele-specific ligase detection reaction (LDR) with free-solution conjugate electrophoresis (FSCE) to generate and analyze the genetic products. FSCE eliminates the need for a po...

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Detalhes bibliográficos
Main Authors: Sinville, Rondedrick, Coyne, Jennifer, Meagher, Robert J., Cheng, Yu-Wei, Barany, Francis, Barron, Annelise, Soper, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010182/
https://ncbi.nlm.nih.gov/pubmed/19053073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elps.200800197
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