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SIRT1 contributes to telomere maintenance and augments global homologous recombination
Yeast Sir2 deacetylase is a component of the silent information regulator (SIR) complex encompassing Sir2/Sir3/Sir4. Sir2 is recruited to telomeres through Rap1, and this complex spreads into subtelomeric DNA via histone deacetylation. However, potential functions at telomeres for SIRT1, the mammali...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010065/ https://ncbi.nlm.nih.gov/pubmed/21187328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201005160 |
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