Deficiency of a Transmembrane Prolyl 4-Hydroxylase in the Zebrafish Leads to Basement Membrane Defects and Compromised Kidney Function

Prolyl 4-hydroxylases (P4Hs) catalyze the hydroxylation of collagens and hypoxia-inducible factor (HIF)-α subunits. We studied the zebrafish homologue of the recently characterized human transmembrane P4H (P4H-TM) that can hydroxylate HIF-α, but not collagens, in vitro and influence HIF-α levels in...

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Detalhes bibliográficos
Main Authors: Hyvärinen, Jaana, Parikka, Mataleena, Sormunen, Raija, Rämet, Mika, Tryggvason, Karl, Kivirikko, Kari I., Myllyharju, Johanna, Koivunen, Peppi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009928/
https://ncbi.nlm.nih.gov/pubmed/20952382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145904
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