Nonamyloid Aggregates Arising from Mature Copper/Zinc Superoxide Dismutases Resemble Those Observed in Amyotrophic Lateral Sclerosis

Protein aggregation is a hallmark of many diseases, including amyotrophic lateral sclerosis (ALS) where aggregation of copper/zinc superoxide dismutase (SOD1) is implicated in pathogenesis. We report here that fully metallated (holo) SOD1 under physiologically relevant solution conditions can underg...

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Detalhes bibliográficos
Main Authors: Hwang, Young-Mi, Stathopulos, Peter B., Dimmick, Kristin, Yang, Hong, Badiei, Hamid R., Tong, Ming Sze, Rumfeldt, Jessica A. O., Chen, Pu, Karanassios, Vassili, Meiering, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009897/
https://ncbi.nlm.nih.gov/pubmed/20974846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113696
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