Frataxin Depletion in Yeast Triggers Up-regulation of Iron Transport Systems before Affecting Iron-Sulfur Enzyme Activities

The primary function of frataxin, a mitochondrial protein involved in iron homeostasis, remains controversial. Using a yeast model of conditional expression of the frataxin homologue YFH1, we analyzed the primary effects of YFH1 depletion. The main conclusion unambiguously points to the up-regulatio...

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Bibliographic Details
Main Authors: Moreno-Cermeño, Armando, Obis, Èlia, Bellí, Gemma, Cabiscol, Elisa, Ros, Joaquim, Tamarit, Jordi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009893/
https://ncbi.nlm.nih.gov/pubmed/20956517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149443
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