Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor.

We have studied the effects of nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) on epidermal growth factor (EGF) binding to PC12 cells. We show that NGF and bFGF rapidly induce a reduction in 125I-EGF binding to PC12 cells in a dose-dependent manner. This decrease amounts to 50% f...

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Publicat a:Mol Biol Cell
Autors principals: Mothe, I, Ballotti, R, Tartare, S, Kowalski-Chauvel, A, Van Obberghen, E
Format: Artigo
Idioma:Inglês
Publicat: American Society for Cell Biology 1993
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC300983/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8400459/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.4.7.737
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