Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome

A large fraction of the mammalian genome is transcribed into long noncoding RNAs. The RNAs remain largely uncharacterized as the field awaits new technologies to aid functional analysis. Here, we describe a unique use of locked nucleic acids (LNAs) for studying nuclear long noncoding RNA, an RNA sub...

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Bibliographic Details
Main Authors: Sarma, Kavitha, Levasseur, Pierre, Aristarkhov, Alexander, Lee, Jeannie T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009817/
https://ncbi.nlm.nih.gov/pubmed/21135235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009785107
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