Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination

Ig class switch recombination (CSR) requires expression of activation-induced cytidine deaminase (AID) and transcription through target switch (S) regions. Here we show that knockdown of the histone chaperone facilitates chromatin transcription (FACT) completely inhibited S region cleavage and CSR i...

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Main Authors: Stanlie, Andre, Aida, Masatoshi, Muramatsu, Masamichi, Honjo, Tasuku, Begum, Nasim A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009800/
https://ncbi.nlm.nih.gov/pubmed/21139053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016923108
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