JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease marked by bone and cartilage destruction. Current biologic therapies are beneficial in only a portion of patients; hence small molecules targeting key pathogenic signaling cascades represent alternative therapeutic strategies. Here we show...

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Bibliographic Details
Main Authors: Guma, Monica, Kashiwakura, Jun-ichi, Crain, Brian, Kawakami, Yuko, Beutler, Bruce, Firestein, Gary S., Kawakami, Toshiaki, Karin, Michael, Corr, Maripat
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009768/
https://ncbi.nlm.nih.gov/pubmed/21135226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016401107
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