The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression

BACKGROUND: The PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase (PI3K) activation. PTEN expression has been shown to be decreased in colorectal cancer. Little is known however as to the specific cellular role of PTEN in human intestinal...

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Hauptverfasser: Langlois, Marie-Josée, Bergeron, Sébastien, Bernatchez, Gérald, Boudreau, François, Saucier, Caroline, Perreault, Nathalie, Carrier, Julie C., Rivard, Nathalie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009737/
https://ncbi.nlm.nih.gov/pubmed/21203412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015742
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