Five vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding

Conserved vertebrate transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To explore the evolution of gene regulation, we experimentally determined the genome-wide occupancy of two TFs, CEBPA and HNF4A, in livers of multiple vertebrates. Although each TF displays...

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Hauptverfasser: Schmidt, Dominic, Wilson, Michael D., Ballester, Benoit, Schwalie, Petra C., Brown, Gordon D., Marshall, Aileen, Kutter, Claudia, Watt, Stephen, Martinez-Jimenez, Celia P., Mackay, Sarah, Talianidis, Iannis, Flicek, Paul, Odom, Duncan T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008766/
https://ncbi.nlm.nih.gov/pubmed/20378774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1186176
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