Vaccination with Ad5 Vectors Expands Ad5-Specific CD8(+) T Cells without Altering Memory Phenotype or Functionality

BACKGROUND: Adenoviral (Ad) vaccine vectors represent both a vehicle to present a novel antigen to the immune system as well as restimulation of immune responses against the Ad vector itself. To what degree Ad-specific CD8(+) T cells are restimulated by Ad vector vaccination is unclear, although suc...

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Main Authors: Hutnick, Natalie A., Carnathan, Diane G., Dubey, Sheri A., Cox, Kara S., Kierstead, Lisa, Makadonas, George, Ratcliffe, Sarah J., Lasaro, Marcio O., Robertson, Michael N., Casimiro, Danilo R., Ertl, Hildegund C. J., Betts, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008674/
https://ncbi.nlm.nih.gov/pubmed/21203546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014385
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