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Automated construction and testing of multi-locus gene–gene associations

Summary: It has been argued that the missing heritability in common diseases may be in part due to rare variants and gene–gene effects. Haplotype analyses provide more power for rare variants and joint analyses across genes can address multi-gene effects. Currently, methods are lacking to perform jo...

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Autors principals: Abo, Ryan, Knight, Stacey, Thomas, Alun, Camp, Nicola J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008644/
https://ncbi.nlm.nih.gov/pubmed/21076150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq616
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