A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants

BACKGROUND: Defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested MUTYH mono-allelic variants...

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Detalhes bibliográficos
Main Authors: Theodoratou, E, Campbell, H, Tenesa, A, Houlston, R, Webb, E, Lubbe, S, Broderick, P, Gallinger, S, Croitoru, E M, Jenkins, M A, Win, A K, Cleary, S P, Koessler, T, Pharoah, P D, Küry, S, Bézieau, S, Buecher, B, Ellis, N A, Peterlongo, P, Offit, K, Aaltonen, L A, Enholm, S, Lindblom, A, Zhou, X-L, Tomlinson, I P, Moreno, V, Blanco, I, Capellà, G, Barnetson, R, Porteous, M E, Dunlop, M G, Farrington, S M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008602/
https://ncbi.nlm.nih.gov/pubmed/21063410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605966
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