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Host cyclooxygenase-2 modulates carcinoma growth

Cyclooxygenase-2 (COX-2; Ptgs2) acts as a tumor promoter in rodent models for colorectal cancer, but its precise role in carcinogenesis remains unclear. We evaluated the contribution of host-derived COX-1 and COX-2 in tumor growth using both genetic and pharmacological approaches. Lewis lung carcino...

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Bibliographic Details
Main Authors: Williams, Christopher S., Tsujii, Masahiko, Reese, Jeff, Dey, Sudhansu K., DuBois, Raymond N.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC300858/
https://ncbi.nlm.nih.gov/pubmed/10841517
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