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CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice

Stable engraftment of human lymphoid tissue in NOD/scid-IL-2Rγ(c)(null) mice after CD34(+) hematopoietic stem cell reconstitution permits the evaluation of ongoing HIV-1 infection for weeks to months. We demonstrate that HIV-1 infected rodents developed virus-specific cellular immune responses. CD8(...

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Autors principals: Gorantla, Santhi, Makarov, Edward, Finke-Dwyer, Jennifer, Gebhart, Catherine L., Domm, William, Dewhurst, Stephen, Gendelman, Howard E., Poluektova, Larisa Y.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008566/
https://ncbi.nlm.nih.gov/pubmed/20495069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000438
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